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KMID : 0363320080290041037
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 4 p.1037 ~ p.1047
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Hepatoprotective Effects of GongJin-dan, on Ethanol-mediated Experimental Liver Damage in Rats
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Hur Hyun
Kim Hee-Jun
Park Kyung
Kwak Min-A
Kim Dae-Jun
Byun Joon-Seok
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Abstract
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Background: A traditional Oriental medicine, GongJjn-dan (GJD), is one of the most well-known tonic agents in Korea. Among 6 types of GJD components, antler, red ginseng, and Cornus fructus have shown antioxidant effects, while EtOH-induced tissue damage may be a consequence of oxidative stress.
Objectives & Methods: The hepatoprotective effects of GJD were evaluated on EtOH-mediated experimental liver damaged rats at 50, 100, 250 and 500mg/kg comparing with 100mg/kg of silymarin as a reference drug in the present study. Test substances were dosed once a day for 60 days with oral administration of 20% ethanol 2.5ml/100g body weight twice a day (equivalent to 7.9g ethanol/kg/day). Each of 8 rats per group was selected using body weight at 10 days after acclimatization. Experimental animals were sacrificed after 60 days of continuous oral treatment of test substances with 20% ethanol treatment, and changes on the body weight, liver weight, and serum AST and ALT were observed.
Results: There were dramatic decreases of body weight and increases of liver weight and serum AST and ALT. Similar inhibition effects on the EtOH-induced hepatic damages were detected between equal dosages of GJD and silymarin.
Conclusion: Based on these results. it is concluded that GJD showed clear hepatoprotective effects on EtOH-induced hepatic damage.
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KEYWORD
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Hepatoprotective, GongJjn-dan, Ethanol-mediated, Liver damage
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